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1   Kwon AT, Chou AY, Arenillas DJ, Wasserman WW. Validation of skeletal muscle cis-regulatory module predictions reveals nucleotide composition bias in functional enhancers. PLoS Comput. Biol. 7(12):e1002256. (2011) PMID 22144875

2   Ehrnhoefer DE, Skotte NH, Savill J, Nguyen YT, Ladha S, Cao LP, Dullaghan E, Hayden MR. A quantitative method for the specific assessment of caspase-6 activity in cell culture. PLoS ONE 6(11):e27680. (2011) PMID 22140457

3   Schulze JM, Hentrich T, Nakanishi S, Gupta A, Emberly E, Shilatifard A, Kobor MS. Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev. 25(21):2242-7. (2011) PMID 22056669

4   Graham RK, Ehrnhoefer DE, Hayden MR. Caspase-6 and neurodegeneration. Trends Neurosci. 34(12):646-56. (2011) PMID 22018804

5   Ehrnhoefer DE, Wong BK, Hayden MR. Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development. Nat Rev Drug Discov 10(11):853-67. (2011) PMID 22015920

6   Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, Hayden MR. Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules. Diabetes 60(12):3186-96. (2011) PMID 21998401

7   Tong Y, Ha TJ, Liu L, Nishimoto A, Reiner A, Goldowitz D. Spatial and Temporal Requirements for huntingtin (Htt) in Neuronal Migration and Survival during Brain Development. J. Neurosci. 31(41):14794-9. (2011) PMID 21994396

8   Review (Invited)   Worsley-Hunt R, Bernard V, Wasserman WW. Identification of cis-regulatory sequence variations in individual genome sequences. 3(10):65. (2011) PMID 21989199

9   Ding Y, Zhang L, Wang Y, Huang W, Tang Y, Bai L, Ross CJ, Hayden MR, Liu G. Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL. PLoS ONE 6(9):e25620. (2011) PMID 21980507

10   Carroll JB, Warby SC, Southwell AL, Doty CN, Greenlee S, Skotte N, Hung G, Bennett CF, Freier SM, Hayden MR. Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin. Mol. Ther. 19(12):2178-85. (2011) PMID 21971427

11   Hawkins AK, Ho A, Hayden MR. Lessons from predictive testing for Huntington disease: 25 years on. J. Med. Genet. 48(10):649-50. (2011) PMID 21931167

12   Karasinska JM, Hayden MR. Cholesterol metabolism in Huntington disease. Nat Rev Neurol 7(10):561-72. (2011) PMID 21894212

13   Essex MJ, Thomas Boyce W, Hertzman C, Lam LL, Armstrong JM, Neumann SM, Kobor MS. Epigenetic Vestiges of Early Developmental Adversity: Childhood Stress Exposure and DNA Methylation in Adolescence. Child Dev (2011) PMID 21883162

14   Carroll JB, Southwell AL, Graham RK, Lerch JP, Ehrnhoefer DE, Cao LP, Zhang WN, Deng Y, Bissada N, Henkelman RM, Hayden MR. Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease. Mol Neurodegener 6:59. (2011) PMID 21854568

15   Lin Q, Wei W, Coelho CM, Li X, Baker-Andresen D, Dudley K, Ratnu VS, Boskovic Z, Kobor MS, Sun YE, Bredy TW. The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nat. Neurosci. 14(9):1115-7. (2011) PMID 21841775

16   Ouyang Z, Song M, Güth R, Ha TJ, Larouche M, Goldowitz D. Conserved and differential gene interactions in dynamical biological systems. Bioinformatics 27(20):2851-8. (2011) PMID 21840874

17   Wang AY, Aristizabal MJ, Ryan C, Krogan NJ, Kobor MS. Key functional regions in the histone variant H2A.Z C-terminal docking domain. Mol. Cell. Biol. 31(18):3871-84. (2011) PMID 21791612

18   Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, Davis NG, Raymond LA, Hayden MR. Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum. Mol. Genet. 20(20):3899-909. (2011) PMID 21775500

19   Vilariño-Güell C, Wider C, Ross OA, Dachsel JC, Kachergus JM, Lincoln SJ, Soto-Ortolaza AI, Cobb SA, Wilhoite GJ, Bacon JA, Behrouz B, Melrose HL, Hentati E, Puschmann A, Evans DM, Conibear E, Wasserman WW, Aasly JO, Burkhard PR, Djaldetti R, Ghika J, Hentati F, Krygowska-Wajs A, Lynch T, Melamed E, Rajput A, Rajput AH, Solida A, Wu RM, Uitti RJ, Wszolek ZK, Vingerhoets F, Farrer MJ. VPS35 mutations in Parkinson disease. Am. J. Hum. Genet. 89(1):162-7. (2011) PMID 21763482

20   VanderVaart S, Berger H, Sistonen J, Madadi P, Matok I, Gijsen VM, de Wildt SN, Taddio A, Ross CJ, Carleton BC, Hayden MR, Koren G. CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study. Ther Drug Monit 33(4):425-32. (2011) PMID 21743374

21   Sivananthan SN, Leavitt BR. Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice. (2011) PMID 21741126

22   Aubrecht J, Goad ME, Czopik AK, Lerner CP, Johnson KA, Simpson EM, Schiestl RH. A high G418-resistant neo(R) transgenic mouse and mouse embryonic fibroblast (MEF) feeder layers for cytotoxicity and gene targeting in vivo and in vitro. (2011) PMID 21740348

23   Fulton DL, Denarier E, Friedman HC, Wasserman WW, Peterson AC. Towards resolving the transcription factor network controlling myelin gene expression. Nucleic Acids Res. 39(18):7974-91. (2011) PMID 21729871

24   Joly Y, Koutrikas G, Ramos-Paque E, Zawati M, Gardy J, Hayden MR, Carleton BC. Diagnostic testing for vaccinomics: is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe. OMICS 15(9):597-605. (2011) PMID 21728814

25   Leung GP, Lee L, Schmidt TI, Shirahige K, Kobor MS. Rtt107 Is Required for Recruitment of the SMC5/6 Complex to DNA Double Strand Breaks. J. Biol. Chem. 286(29):26250-7. (2011) PMID 21642432

26   Leung GP, Lee L, Schmidt TI, Shirahige K, Kobor MS. Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks. J. Biol. Chem. 286(29):26250-7. (2011) PMID 21642432

27   Rogers TD, Dickson PE, Heck DH, Goldowitz D, Mittleman G, Blaha CD. Connecting the dots of the cerebro-cerebellar role in cognitive function: Neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex. Synapse 65(11):1204-12. (2011) PMID 21638338

28   Huang K, Sanders SS, Kang R, Carroll JB, Sutton L, Wan J, Singaraja R, Young FB, Liu L, El-Husseini A, Davis NG, Hayden MR. Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14. Hum. Mol. Genet. 20(17):3356-65. (2011) PMID 21636527

29   Review   Weir DW, Sturrock A, Leavitt BR. Development of biomarkers for Huntington's disease. Lancet Neurol 10(6):573-90. (2011) PMID 21601164

30   Cotton AM, Lam L, Affleck JG, Wilson IM, Peñaherrera MS, McFadden DE, Kobor MS, Lam WL, Robinson WP, Brown CJ. Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation. Hum. Genet. 130(2):187-201. (2011) PMID 21597963

31   Lenstra TL, Benschop JJ, Kim T, Schulze JM, Brabers NA, Margaritis T, van de Pasch LA, van Heesch SA, Brok MO, Groot Koerkamp MJ, Ko CW, van Leenen D, Sameith K, van Hooff SR, Lijnzaad P, Kemmeren P, Hentrich T, Kobor MS, Buratowski S, Holstege FC. The specificity and topology of chromatin interaction pathways in yeast. Mol. Cell 42(4):536-49. (2011) PMID 21596317

32   Review   Reynolds JN, Weinberg J, Clarren S, Beaulieu C, Rasmussen C, Kobor M, Dube MP, Goldowitz D. Fetal alcohol spectrum disorders: gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes. Semin Pediatr Neurol 18(1):49-55. (2011) PMID 21575841

33   Portales-Casamar E, Evans A, Wasserman W, Pavlidis P. The NeuroDevNet Neuroinformatics Core. Semin Pediatr Neurol 18(1):17-20. (2011) PMID 21575836

34   Review   Lewis NJ, Goldowitz D. NeuroDevNet: A Canada Network of Centres of Excellence--to realize a vision by effective operations and collaborative mechanisms. Semin Pediatr Neurol 18(1):5-9. (2011) PMID 21575834

35   Review   Goldowitz D, McArthur D. The NeuroDevNet vision. Semin Pediatr Neurol 18(1):2-4. (2011) PMID 21575833

36   Review   Shevell M, Goldowitz D. Inter-disciplinary research in the pediatric neurosciences: the NeuroDevNet model. Introduction. Semin Pediatr Neurol 18(1):1. (2011) PMID 21575832

37   Yuen RK, Neumann SM, Fok AK, Penaherrera MS, McFadden DE, Robinson WP, Kobor MS. Extensive epigenetic reprogramming in human somatic tissues between fetus and adult. 4(1):7. (2011) PMID 21545704

38   Brunham L, Tietjen I, Bochem A, Singaraja R, Franchini P, Radomski C, Mattice M, Legendre A, Hovingh G, Kastelein J, Hayden M. Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans. Clin. Genet. 79(6):575-81. (2011) PMID 21480869

39   Takahashi YH, Schulze JM, Jackson J, Hentrich T, Seidel C, Jaspersen SL, Kobor MS, Shilatifard A. Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing. Mol. Cell 42(1):118-26. (2011) PMID 21474073

40   Madadi P, Joly Y, Avard D, Chitayat DC, Smith MA, D Ross CJ, Carleton BC, Hayden MR, Koren G. The communication of pharmacogenetic research results: participants weigh in on their informational needs in a pilot study. J Popul Ther Clin Pharmacol 18:e152-5. (2011) PMID 21467605

41   Ross CJ, Visscher H, Rassekh SR, Castro-Pastrana LI, Shereck E, Carleton B, Hayden MR. Pharmacogenomics of serious adverse drug reactions in pediatric oncology. J Popul Ther Clin Pharmacol 18:e134-51. (2011) PMID 21467604

42   Carroll JB, Lerch JP, Franciosi S, Spreeuw A, Bissada N, Henkelman RM, Hayden MR. Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease. Neurobiol. Dis. 43(1):257-65. (2011) PMID 21458571

43   Choi C, Davey M, Schluter C, Pandher P, Fang Y, Foster LJ, Conibear E. Organization and Assembly of the TRAPPII Complex. (2011) PMID 21453443

44   Visscher H, Amstutz U, Sistonen J, Ross CJ, Hayden MR, Carleton BC. Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics. J. Cardiovasc. Pharmacol. 58(3):228-39. (2011) PMID 21386709

45   Le Béchec A, Portales-Casamar E, Vetter G, Moes M, Zindy PJ, Saumet A, Arenillas D, Theillet C, Wasserman WW, Lecellier CH, Friederich E. MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model. BMC Bioinformatics 12:67. (2011) PMID 21375730

46   Mittleman G, Call SB, Cockroft JL, Goldowitz D, Matthews DB, Blaha CD. Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice. Alcohol 45(4):325-39. (2011) PMID 21354763

47   Di Curzio DL, Goldowitz D. The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice. Mamm. Genome 22(3-4):209-34. (2011) PMID 21347846

48   Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y, Poquiz P, Tjong J, Pouladi MA, Hayden MR, Masliah E, Ellisman M, Rouiller I, Schwarzenbacher R, Bossy B, Perkins G, Bossy-Wetzel E. Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat. Med. 17(3):377-82. (2011) PMID 21336284

49   Ehrnhoefer DE, Sutton L, Hayden MR. Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease. Neuroscientist 17(5):475-92. (2011) PMID 21311053

50   Hawkins AK, Hayden MR. A grand challenge: providing benefits of clinical genetics to those in need. Genet. Med. 13(3):197-200. (2011) PMID 21283011

51   Review   Dudley KJ, Li X, Kobor MS, Kippin TE, Bredy TW. Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. Neurosci Biobehav Rev 35(7):1544-51. (2011) PMID 21251925

52   Warby SC, Visscher H, Collins JA, Doty CN, Carter C, Butland SL, Hayden AR, Kanazawa I, Ross CJ, Hayden MR. HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia. Eur. J. Hum. Genet. 19(5):561-6. (2011) PMID 21248742

53   Ye D, Zhao Y, Hildebrand RB, Singaraja RR, Hayden MR, Van Berkel TJ, Van Eck M. The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Am. J. Pathol. 178(1):413-22. (2011) PMID 21224078

54   Dickson PE, Rogers TD, Lester DB, Miller MM, Matta SG, Chesler EJ, Goldowitz D, Blaha CD, Mittleman G. Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine. Psychopharmacology (Berl.) 215(4):631-42. (2011) PMID 21212937

55   Swanson DJ, Goldowitz D. Experimental Sey mouse chimeras reveal the developmental deficiencies of Pax6-null granule cells in the postnatal cerebellum. Dev. Biol. 351(1):1-12. (2011) PMID 21126516

56   Review   Wang A. TMEM216 joins its ciliary cousins in ciliopathies. Clin. Genet. 79(1):45-7. (2011) PMID 21029074

57   Chen E, Miller GE, Kobor MS, Cole SW. Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Mol. Psychiatry 16(7):729-37. (2011) PMID 20479762

58   Review (Invited)   Taubert S, Ward JD, Yamamoto KR. Nuclear hormone receptors in nematodes: Evolution and function. 334(1-2):49-55. (2011) PMID 20438802

59   Ekaterina Nosova, Giancarlo Raiconi and Roberto Tagliaferri. A Combinatoric biclustering algorithm Neural Nets WIRN10 - Proceedings of the 20th Italian Workshop on Neural Nets 226:44-51. (2011)

60   Review   Kobor MS, and Weinberg J. Epigenetics and Fetal Alcohol Spectrum Disorders. Alcohol Research & Health. 34(1):29-37. (2011)

61   Joly Y, Koutrikas G, Tassé A-M, Issa A, Carleton B, Hayden MR, Rieder MJ, Ramos-Paque E, Avard D. Regulatory Approval for New Pharmacogenomics Tests: A Comparative Overview. Food and Drug Law Journal (2011)