Charles N. de Leeuw | Centre for Molecular Medicine and Therapeutics

FACULTY & STAFF DIRECTORY

Charles N. de Leeuw

BSc

Medical Genetics Graduate Program, UBC

PhD Student

Group	Simpson Lab
Email
Direct line	+1 (604) 875-3853
Fax	+1 (604) 875-3819

ADDITIONAL CONTACT INFORMATION

Location	Room 3032
	Centre for Molecular Medicine and Therapeutics 950 West 28th Avenue Vancouver, BC V5Z 4H4 Canada

TRAINEE INFORMATION

Degree sought	PhD (Medical Genetics)
Thesis topic	The outcome of ectopic and ubiquitous NR2E1 – effects on proliferation, brain development, and behaviour
Grad advisor	Dr. Elizabeth M. Simpson

EDUCATION

BSc (First Class Honours) Molecular Genetics, University of Alberta

RESEARCH INTERESTS

As a member of the Pleiades Promoter Project, I am interested in applying the resources developed by Pleiades to study the role of NR2E1 in determing cell fate and identity.

PROFESSIONAL ACTIVITIES

Committees
   Graduate Student Committee, Faculty of Medicine, UBC (2009-10)
   Departmental/Faculty Meetings Student Representative, Medical Genetics, UBC
   (2009-10)
   Search Committee - Dept. Head, Medical Genetics, UBC (2009-10)
Professional Memberships
   Society for Neuroscience

AWARDS & HONORS

2011
   CMMT Scientific Symposium – Graduate Poster Award
   NeuroDevNet – Travel Award
2008
   Michael Smith Foundation for Health Research – Junior Graduate Scholarship
2007
   Canadian Institutes of Health Research – Canada Graduate Scholarship Master’s    Award
   UBC University Graduate Fellowship - Declined
2006
   Canadian Liver Foundation Summer Studentship
   Dean’s Honor Roll
2005
   Jason Lang Scholarship
   Dean’s Honor Roll
2004
   Jason Lang Scholarship
2002
   University of Alberta Academic Excellence Scholarship for International Students
   Millar-Western Entrance Leadership Scholarship
   University of Alberta Academic Excellence Scholarship
   Faculty of Science Academic Excellence Scholarship

PRESENTATIONS

de Leeuw CN, Laprise S, Banks KG, Portales-Casamar E, Swanson MI, Swanson DJ, Liu L, Dreolini L, Jones SJM, Holt RA, Goldowitz D, Wasserman WW, Simpson EM. New Pleiades MiniPromoters for Brain and Eye. Neuroscience 2011, Washington, DC, USA. Nov. 12-16 2011.
de Leeuw CN, Banks KG, Ali J, Black SF, Bonaguro RJ, Candido TR, Chen J, Chen Y, Cheng JCY, Chopra V, Dreolini L, Flynn EK, Komljenovic I, Lee L, Lithwick S, Liu J, McConechy M, Swanson M, Ticoll A, Vermeulen J, Yang GS, Ypsilanti AR, D’Souza C, Portales-Casamar E, Goldowitz D, Jones SJ, Holt RA, Wasserman WW, Simpson EM. Pleiades MiniPromoter ES cells as tools for region-specific gene therapy delivery in the adult brain. Integrative Approaches to Brain Complexity, Hinxton, UK. Sept. 27-30 2007.

Publications

Journal Articles

1 Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli M, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperriere D, Leprince D, de Cristofaro T, Prince KL, Putker M, Del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner N, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, Lebrun DP, Biswal S, Harvey CJ, Debruyne JP, Hogenesch JB, Hevner RF, Heligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The Transcription Factor Encyclopedia. 13(3):R24. (2012) PMID 22458515

2 Portales-Casamar E, Swanson DJ, Liu L, de Leeuw CN, Banks KG, Ho Sui SJ, Fulton DL, Ali J, Amirabbasi M, Arenillas DJ, Babyak N, Black SF, Bonaguro RJ, Brauer E, Candido TR, Castellarin M, Chen J, Chen Y, Cheng JC, Chopra V, Docking TR, Dreolini L, D'Souza CA, Flynn EK, Glenn R, Hatakka K, Hearty TG, Imanian B, Jiang S, Khorasan-zadeh S, Komljenovic I, Laprise S, Liao NY, Lim JS, Lithwick S, Liu F, Liu J, Lu M, McConechy M, McLeod AJ, Milisavljevic M, Mis J, O'Connor K, Palma B, Palmquist DL, Schmouth JF, Swanson MI, Tam B, Ticoll A, Turner JL, Varhol R, Vermeulen J, Watkins RF, Wilson G, Wong BK, Wong SH, Wong TY, Yang GS, Ypsilanti AR, Jones SJ, Holt RA, Goldowitz D, Wasserman WW, Simpson EM. A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc. Natl. Acad. Sci. U.S.A. 107(38):16589-94. (2010) PMID 20807748

3 Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics 93(3):196-204. (2009) PMID 18950699

Invited Submissions, Books, Chapters, Letters, and Editorials

1 Editorial de Leeuw CN. CMT4J: Charcot-Marie-Tooth disorder caused by mutations in FIG4. Clin. Genet. 73(4):318-9. (2008) PMID 18261132