Alice Y Wang | Centre for Molecular Medicine and Therapeutics

FACULTY & STAFF DIRECTORY

Alice Y Wang

BSc

PhD Student

Group	Kobor Lab
Email
Direct line	+1 (604) 875-3833
Fax	+1 (604) 875-3840

ADDITIONAL CONTACT INFORMATION

Location	Room 2003
	Centre for Molecular Medicine and Therapeutics 950 West 28th Avenue Vancouver, BC V5Z 4H4 Canada

TRAINEE INFORMATION

Degree sought	PhD
Thesis topic	Mechanism of Histone Variant H2A.Z Deposition and Function
Grad advisor	Dr. Michael S. Kobor

RESEARCH INTERESTS

One of the fundamental ways that the chromatin structure can be altered is the replacement of canonical histones with non-allelic histone variants. Rather than being distributed randomly across the genome, histone variants are often found in specific locations, thus creating distinct chromosome neighborhoods. I study one such variant, H2A.Z in the budding yeast Saccharomyces cerevisiae. H2A.Z is conserved from yeast to human and replaces canonical H2A in 5-10% of nucleosomes. My research focuses on deciphering the fundamental structural and functional differences between H2A and H2A.Z using a combination of genetic, biochemical and genomic approaches. My goal is to identify regions in H2A.Z conferring functional differences from H2A.

AWARDS & HONORS

Canadian Institute of Health Research (CIHR) - Frederick Banting and Charles Best Canada Graduate Scholarships - Doctoral Award - 2009-2012
Michael Smith Foundation for Health Research (MSFHR) - Junior Graduate Studentship - 2007-2009

Publications

Reviews and Invited Reviews

1 Review Wang A. TMEM216 joins its ciliary cousins in ciliopathies. Clin. Genet. 79(1):45-7. (2011) PMID 21029074

2 Review (Invited) Schulze JM, Wang AY, Kobor MS. Reading chromatin: insights from yeast into YEATS domain structure and function. Epigenetics 5(7):573-7. (2010) PMID 20657183

3 Review (Invited) Schulze JM, Wang AY, Kobor MS. YEATS domain proteins: a diverse family with many links to chromatin modification and transcription. Biochem. Cell Biol. 87(1):65-75. (2009) PMID 19234524

Journal Articles

1 Wang AY, Aristizabal MJ, Ryan C, Krogan NJ, Kobor MS. Key functional regions in the histone variant H2A.Z C-terminal docking domain. Mol. Cell. Biol. 31(18):3871-84. (2011) PMID 21791612

2 Halley JE, Kaplan T, Wang AY, Kobor MS, Rine J. Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory. PLoS Biol. 8(6):e1000401. (2010) PMID 20582323

3 Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc. Natl. Acad. Sci. U.S.A. 106(51):21573-8. (2009) PMID 19966225