Simon C. Warby | Centre for Molecular Medicine and Therapeutics

FACULTY & STAFF DIRECTORY

Simon C. Warby

PhD

Alumni

Previous Position:	Postdoctoral Research Fellow,
	Hayden Lab

ALUMNI INFORMATION

No information available

EDUCATION

PhD (Neuroscience) University of British Columbia, 2007
BSc (Hons) (Biology Co-Op) University of Victoria, 1998
BSc (Psychology) University of Victoria, 1998

AWARDS & HONORS

Canadian Institutes of Health Research
CGS Doctoral Research Award (2004 – 2007)

Michael Smith Foundation for Health Research
Senior Graduate Scholarship (2004 – 2007)

BC Research Institute & Children and Women’s Hospital
New Studentship (2003 – 2005)

Huntington Society of Canada
Landmark Graduate Award (2000 – 2003)

PRESENTATIONS

Role of phosphorylation at S421 in the caspase cleavage of huntingtin.
Warby SC, Doty C, Graham R, Deng Y, and Hayden MR.: Hereditary Disease Foundation, Boston, 2006. (Poster); Neurons and Disease Conference, Atlanta, 2006. (Poster); Society for Neuroscience, Atlanta, 2006. (Poster); Neuroscience Research Day, UBC, 2006. (Winner Poster Competition)

Detailed haplotype analysis of the HD gene.
Warby SC, Montpetit A, Serre D, Collins J, Hayden A, Hudson TJ, Hayden MR.: Biology of Genomes, Cold Spring Harbour Laboratories, NY, 2006 (Poster); CFRI Research Day, Vancouver 2006. (Poster – Winner Poster Competition); Canadian Genetic Disease Network, Saint- Sauveur, Quebec, 2006. (Oral Presentation)

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Warby SC, Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR.: Society for Neuroscience, Washington, D.C. 2005. (Poster); HDSA Congress, Manchester, 2005. (Oral Presentation); Huntington Disease Society of America, Cleveland, 2004. (Poster); Neuroscience Research Day, UBC, 2004. (Poster)

Huntingtin 7246T>C Polymorphism is Underrepresented on Huntington Disease Chromosomes.
Warby SC, Devon R, Collins J, Hayden MR.: Canadian Genetic Disease Network Conference, Kananaskis, Alberta, 2003. (Poster)

Publications

Journal Articles

1 Warby SC, Montpetit A, Hayden AR, Carroll JB, Butland SL, Visscher H, Collins JA, Semaka A, Hudson TJ, Hayden MR. CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup. Am. J. Hum. Genet. (2009) PMID 19249009

2 Warby SC, Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR. Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments. Mol. Cell. Neurosci. 40(2):121-7. (2009) PMID 18992820

3 Semaka A, Warby S, Leavitt BR, Hayden MR. Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats. Mov. Disord. 23(12):1794-5; author reply 1793. (2008) PMID 18548612

4 Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR. Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus. Hum. Mol. Genet. 17(15):2390-404. (2008) PMID 18445618

5 Van Raamsdonk JM, Warby SC, Hayden MR. Selective degeneration in YAC mouse models of Huntington disease. Brain Res. Bull. 72(2-3):124-31. (2007) PMID 17352936

6 Semaka A, Creighton S, Warby S, Hayden MR. Predictive testing for Huntington disease: interpretation and significance of intermediate alleles. Clin. Genet. 70(4):283-94. (2006) PMID 16965319

7 Kishikawa S, Li JL, Gillis T, Hakky MM, Warby S, Hayden M, MacDonald ME, Myers RH, Gusella JF. Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Neurobiol. Dis. 24(2):280-5. (2006) PMID 16962786

8 Li JL, Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gómez-Tortosa E, García CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djoussé L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med. Genet. 7:71. (2006) PMID 16914060

9 Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125(6):1179-91. (2006) PMID 16777606

10 Warby S, MacDonald M, Hayden M, Butland S, Ouellette F. FASA-57 cDNA shares no homology with coding sequence of HD gene. J. Reprod. Immunol. 69(1):9-10; author reply 11. (2006) PMID 16386309

11 Warby SC, Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR. Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. Hum. Mol. Genet. 14(11):1569-77. (2005) PMID 15843398

12 Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum. Mol. Genet. 11(23):2815-28. (2002) PMID 12393793

13 Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J. Neurosci. 22(18):7862-72. (2002) PMID 12223539

14 Hackam AS, Yassa AS, Singaraja R, Metzler M, Gutekunst CA, Gan L, Warby S, Wellington CL, Vaillancourt J, Chen N, Gervais FG, Raymond L, Nicholson DW, Hayden MR. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. J. Biol. Chem. 275(52):41299-308. (2000) PMID 11007801