Elizabeth M. Simpson
FACULTY & STAFF DIRECTORY
Profile photo
Elizabeth M. Simpson
BSc, MSc, PhD
Senior Scientist, Centre for Molecular Medicine and Therapeutics (CMMT)
Scientist Level 3, Child & Family Research Institute
Professor, Department of Medical Genetics, UBC
Associate Member, Department of Psychiatry, UBC
Associate Member, Department of Ophthalmology & Visual Sciences, UBC
Principal Investigator
Group Simpson Lab
Email
Direct line +1 (604) 875-3830
Fax

ADDITIONAL CONTACT INFORMATION

Location Room 3020
 
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada

RESEARCH INTERESTS

Please visit my lab website to learn more about my research interests and projects.

Publications

Journal Articles

1   Corso-Diaz X, de Leeuw CN, Alonso V, Melchers D, Wong BK, Houtman R, Simpson EM. . Co-activator candidate interactions for orphan nuclear receptor NR2E1. BMC Genomics 17(1):832. (2016) PMID 27782803
2   Hickmott, J.W., Chen, C.Y., Arenillas, D.J., Korecki, A.J., Lam, S.L., Molday, L.L., Bonaguro, R.J., Zhou, M., Chou, A.Y., Mathelier, A., Boye, S.L., Hauswirth, W.W., Molday, R.S., Wasserman, W.W., and Simpson, E.M. . PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina. Mol Ther Methods Clin Dev. (2016) PMID 27556059
3   de Leeuw CN, Korecki AJ, Berry GE, Hickmott JW, Lam SL, Lengyell TC, Bonaguro RJ, Borretta LJ, Chopra V, Chou AY, D'Souza CA, Kaspieva O, Laprise S, McInerny SC, Portales-Casamar E, Swanson-Newman MI, Wong K, Yang GS, Zhou M, Jones SJ, Holt RA, Asokan A, Goldowitz D, Wasserman WW, Simpson EM.. rAAV-compatible MiniPromoters for restricted expression in the brain and eye. Mol Brain. 9(1):52. (2016) PMID 27164903
4   Scalabrino ML, Boye SL, Fransen KM, Noel JM, Dyka FM, Min SH, Ruan Q, De Leeuw CN, Simpson EM, Gregg RG, McCall MA, Peachey NS, Boye SE. Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. Hum. Mol. Genet. (2015) PMID 26310623
5   Schmouth J.F., Arenillas D., Corso-Diaz X., Xie Y.Y., Bohacec S., Banks K.G., Bonaguro R.J., Wong S.H., Jones S.J., Marra M.A., Simpson E.M., Wasserman W.W. Combined serial analysis of gene expression and transcription factor binding site prediction identifies novel-candidate-target genes of Nr2e1 in neocortex development. BMC Genomics 16:545. (2015) PMID 26204903
6   Corso-Díaz X, Simpson E.M.. Nr2e1 regulates retinal lamination and the development of Muller glia, S-cones, and glycineric amacrine cells during retinogenesis. Mol Brain 8:37. (2015) PMID 26092486
7   de Leeuw CN, Dyka FM, Boye SL, Laprise S, Zhou M, Chou AY, Borretta L, McInerny SC, Banks KG, Portales-Casamar E, Swanson MI, D'Souza CA, Boye SE, Jones SJ, Holt RA, Goldowitz D, Hauswirth WW, Wasserman WW, Simpson EM. Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors. Mol Ther Methods Clin Dev 1:5. (2014) PMID 24761428
8   Schmouth JF, Castellarin M, Laprise S, Banks KG, Bonaguro RJ, McInerny SC, Borretta L, Amirabbasi M, Korecki AJ, Portales-Casamar E, Wilson G, Dreolini L, Jones SJ, Wasserman WW, Goldowitz D, Holt RA, Simpson EM. Non-coding-regulatory regions of human brain genes delineated by BAC knock-in mice. BMC Biol. 11(1):106. (2013) PMID 24124870
9   Corso-Díaz X, Borrie AE, Bonaguro R, Schuetz JM, Rosenberg T, Jensen H, Brooks BP, Macdonald IM, Pasutto F, Walter MA, Grønskov K, Brooks-Wilson A, Simpson EM. Absence of NR2E1 mutations in patients with aniridia. Mol. Vis. 18:2770-82. (2012) PMID 23213277
10   Yang C, McLeod AJ, Cotton AM, de Leeuw CN, Laprise S, Banks KG, Simpson EM, Brown CJ. Targeting of >1.5 Mb of Human DNA into the Mouse X Chromosome Reveals Presence of cis-acting Regulators of Epigenetic Silencing. Genetics 192(4):1281-93. (2012) PMID 23023002
11   Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Kent Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Francis Stewart A, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. The mammalian gene function resource: the international knockout mouse consortium. Mamm. Genome 23(9-10):580-6. (2012) PMID 22968824
12   Murray SA, Eppig JT, Smedley D, Simpson EM, Rosenthal N. Beyond knockouts: cre resources for conditional mutagenesis. Mamm. Genome 23(9-10):587-99. (2012) PMID 22926223
13   Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli M, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperriere D, Leprince D, de Cristofaro T, Prince KL, Putker M, Del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner N, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, Lebrun DP, Biswal S, Harvey CJ, Debruyne JP, Hogenesch JB, Hevner RF, Heligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The Transcription Factor Encyclopedia. 13(3):R24. (2012) PMID 22458515
14   Schmouth JF, Bonaguro RJ, Corso-Diaz X, Simpson EM. Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing. PLoS Genet. 8(3):e1002544. (2012) PMID 22396661
15   Schmouth JF, Banks KG, Mathelier A, Gregory-Evans CY, Castellarin M, Holt R, Gregory-Evans K, Wasserman WW, Simpson EM. Retina Restored and Brain Abnormalities Ameliorated by Single-Copy Knock in of Human NR2E1 in Null Mice. (2012) PMID 22290436
16   Aubrecht J, Goad ME, Czopik AK, Lerner CP, Johnson KA, Simpson EM, Schiestl RH. A high G418-resistant neo(R) transgenic mouse and mouse embryonic fibroblast (MEF) feeder layers for cytotoxicity and gene targeting in vivo and in vitro. (2011) PMID 21740348
17   Portales-Casamar E, Swanson DJ, Liu L, de Leeuw CN, Banks KG, Ho Sui SJ, Fulton DL, Ali J, Amirabbasi M, Arenillas DJ, Babyak N, Black SF, Bonaguro RJ, Brauer E, Candido TR, Castellarin M, Chen J, Chen Y, Cheng JC, Chopra V, Docking TR, Dreolini L, D'Souza CA, Flynn EK, Glenn R, Hatakka K, Hearty TG, Imanian B, Jiang S, Khorasan-zadeh S, Komljenovic I, Laprise S, Liao NY, Lim JS, Lithwick S, Liu F, Liu J, Lu M, McConechy M, McLeod AJ, Milisavljevic M, Mis J, O'Connor K, Palma B, Palmquist DL, Schmouth JF, Swanson MI, Tam B, Ticoll A, Turner JL, Varhol R, Vermeulen J, Watkins RF, Wilson G, Wong BK, Wong SH, Wong TY, Yang GS, Ypsilanti AR, Jones SJ, Holt RA, Goldowitz D, Wasserman WW, Simpson EM. A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc. Natl. Acad. Sci. U.S.A. 107(38):16589-94. (2010) PMID 20807748
18   Wong BK, Hossain SM, Trinh E, Ottmann GA, Budaghzadeh S, Zheng QY, Simpson EM. Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice. Genes Brain Behav. 9(7):681-94. (2010) PMID 20497236
19   Milisavljevic M, Hearty T, Wong TY, Portales-Casamar E, Simpson EM, Wasserman WW. Laboratory Animal Management Assistant (LAMA): a LIMS for active research colonies. Mamm. Genome 21(5-6):224-30. (2010) PMID 20411264
20   Mazarei G, Neal SJ, Becanovic K, Luthi-Carter R, Simpson EM, Leavitt BR. Expression analysis of novel striatal-enriched genes in Huntington disease. Hum. Mol. Genet. 19(4):609-22. (2010) PMID 19934114
21   Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457(7229):599-602. (2009) PMID 19078957
22   Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics 93(3):196-204. (2009) PMID 18950699
23   D'Souza CA, Chopra V, Varhol R, Xie YY, Bohacec S, Zhao Y, Lee LL, Bilenky M, Portales-Casamar E, He A, Wasserman WW, Goldowitz D, Marra MA, Holt RA, Simpson EM, Jones SJ. Identification of a set of genes showing regionally enriched expression in the mouse brain. BMC Neurosci 9:66. (2008) PMID 18625066
24   Kumar RA, McGhee KA, Leach S, Bonaguro R, Maclean A, Aguirre-Hernandez R, Abrahams BS, Coccaro EF, Hodgins S, Turecki G, Condon A, Muir WJ, Brooks-Wilson AR, Blackwood DH, Simpson EM. Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B(6):880-9. (2008) PMID 18205168
25   Oberlander TF, Bonaguro RJ, Misri S, Papsdorf M, Ross CJ, Simpson EM. Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications. Mol. Psychiatry 13(1):65-73. (2008) PMID 17519929
26   Kumar RA, Everman DB, Morgan CT, Slavotinek A, Schwartz CE, Simpson EM. Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes. BMC Med. Genet. 8:48. (2007) PMID 17655765
27   Kumar RA, Leach S, Bonaguro R, Chen J, Yokom DW, Abrahams BS, Seaver L, Schwartz CE, Dobyns W, Brooks-Wilson A, Simpson EM. Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations. Genes Brain Behav. 6(6):503-16. (2007) PMID 17054721
28   Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW. Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev. Biol. 300(2):523-33. (2006) PMID 17027958
29   Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, McCaffery JM, El-Husseini AE, Leavitt BR, Hayden MR. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc. Natl. Acad. Sci. U.S.A. 103(25):9595-600. (2006) PMID 16769894
30   Kuo BY, Chen Y, Bohacec S, Johansson O, Wasserman WW, Simpson EM. SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. PLoS Comput. Biol. 2(4):e34. (2006) PMID 16683015
31   Christie BR, Li AM, Redila VA, Booth H, Wong BK, Eadie BD, Ernst C, Simpson EM. Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus. Neuroscience 137(3):1031-7. (2006) PMID 16289828
32   Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charest D, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman B, Holt RA, Hou J, Kuo BY, Lee LL, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu AL, Pandoh P, Riggins GJ, de Algara TR, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie YY, Yang G, Zhang I, Hirst M, Jones SJ, Helgason CD, Simpson EM, Hoodless PA, Marra MA. A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. Proc. Natl. Acad. Sci. U.S.A. 102(51):18485-90. (2005) PMID 16352711
33   Abrahams BS, Kwok MC, Trinh E, Budaghzadeh S, Hossain SM, Simpson EM. Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1. J. Neurosci. 25(27):6263-70. (2005) PMID 16000615
34   Janssen PA, Nicholls TL, Kumar RA, Stefanakis H, Spidel AL, Simpson EM. Of mice and men: will the intersection of social science and genetics create new approaches for intimate partner violence? J Interpers Violence 20(1):61-71. (2005) PMID 15618562
35   Houde C, Banks KG, Coulombe N, Rasper D, Grimm E, Roy S, Simpson EM, Nicholson DW. Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice. J. Neurosci. 24(44):9977-84. (2004) PMID 15525783
36   Fedele DE, Koch P, Scheurer L, Simpson EM, Möhler H, Brüstle O, Boison D. Engineering embryonic stem cell derived glia for adenosine delivery. Neurosci. Lett. 370(2-3):160-5. (2004) PMID 15488315
37   Hossain SM, Wong BK, Simpson EM. The dark phase improves genetic discrimination for some high throughput mouse behavioral phenotyping. Genes Brain Behav. 3(3):167-77. (2004) PMID 15140012
38   Kumar RA, Chan KL, Wong AH, Little KQ, Rajcan-Separovic E, Abrahams BS, Simpson EM. Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice. Genesis 38(2):51-7. (2004) PMID 14994267
39   Banks KG, Johnson KA, Lerner CP, Mahaffey CL, Bronson RT, Simpson EM. Retroposon compensatory mechanism hypothesis not supported: Zfa knockout mice are fertile. Genomics 82(3):254-60. (2003) PMID 12906850
40   Abrahams BS, Chong AC, Nisha M, Milette D, Brewster DA, Berry ML, Muratkhodjaev F, Mai S, Rajcan-Separovic E, Simpson EM. Metaphase FISHing of transgenic mice recommended: FISH and SKY define BAC-mediated balanced translocation. Genesis 36(3):134-41. (2003) PMID 12872244
41   Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 12(13):1555-67. (2003) PMID 12812983
42   Simpson EM, Johnson KA, Shirley BJ, Fang GY, Bayleran JK, Lerner CP. Novel Sxr(a) ES cell line offers hope for Y chromosome gene-targeted mice. Genesis 33(2):62-6. (2002) PMID 12112873
43   Abrahams BS, Mak GM, Berry ML, Palmquist DL, Saionz JR, Tay A, Tan YH, Brenner S, Simpson EM, Venkatesh B. Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci. Genomics 80(1):45-53. (2002) PMID 12079282
44   Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY, Smith RS, Bronson RT, Nelson RJ, Simpson EM. Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav. Brain Res. 132(2):145-58. (2002) PMID 11997145
45   Linnell ER, Lerner CP, Johnson KA, Leach CA, Ulrich TR, Rafferty WC, Simpson EM. Transgenic mice for the preparation of puromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selection. Mamm. Genome 12(2):169-71. (2001) PMID 11210188
46   Collins EC, Pannell R, Simpson EM, Forster A, Rabbitts TH. Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 1(2):127-32. (2000) PMID 11265751
47   Festing MF, Simpson EM, Davisson MT, Mobraaten LE. Revised nomenclature for strain 129 mice. Mamm. Genome 10(8):836. (1999) PMID 10430671
48   Bergstrom DE, Grieco DA, Sonti MM, Fawcett JJ, Bell-Prince C, Cram LS, Narayanswami S, Simpson EM. The mouse Y chromosome: enrichment, sizing, and cloning by bivariate flow cytometry. Genomics 48(3):304-13. (1998) PMID 9545635
49   George JF, Sweeney SD, Kirklin JK, Simpson EM, Goldstein DR, Thomas JM. An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow. Nat. Med. 4(3):333-5. (1998) PMID 9500608
50   Silva AJ, Simpson EM, Takahashi JS, Lipp H-P, Nakanishi S, Wehner JM, Giese KP, Tully T, Abel T, Chapman PF, Fox K, Grant S, Itohara S, Lathe R, Mayford M, McNamara JO, Morris RJ, Picciotto M, Roder J, Shin H-S, Slesinger PA, Storm DR, Stryker MP, Tonegawa S, Wang Y, and Wolfer DP. Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. Neuron 19(4):755-9. (1997) PMID 9354323
51   Bergstrom DE, Yan H, Sonti MM, Narayanswami S, Bayleran JK, Simpson EM. An expanded collection of mouse Y chromosome RDA clones. Mamm. Genome 8(7):510-2. (1997) PMID 9195997
52   Mbikay M, Tadros H, Ishida N, Lerner CP, De Lamirande E, Chen A, El-Alfy M, Clermont Y, Seidah NG, Chrétien M, Gagnon C, Simpson EM. Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc. Natl. Acad. Sci. U.S.A. 94(13):6842-6. (1997) PMID 9192653
53   Aubrecht J, Goad ME, Simpson EM, Schiestl RH. Expression of hygR in transgenic mice causes resistance to toxic effects of hygromycin B in vivo. J. Pharmacol. Exp. Ther. 281(2):992-7. (1997) PMID 9152410
54   Simpson EM, Linder CC, Sargent EE, Davisson MT, Mobraaten LE, Sharp JJ. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat. Genet. 16(1):19-27. (1997) PMID 9140391
55   Enerbäck S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387(6628):90-4. (1997) PMID 9139827
56   Mahaffey CL, Bayleran JK, Yeh GY, Lee TC, Page DC, Simpson EM. Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family. Genomics 41(1):123-7. (1997) PMID 9126493
57   Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6(3):303-13. (1997) PMID 9075931
58   Navin A, Prekeris R, Lisitsyn NA, Sonti MM, Grieco DA, Narayanswami S, Lander ES, Simpson EM. Mouse Y-specific repeats isolated by whole chromosome representational difference analysis. Genomics 36(2):349-53. (1996) PMID 8812464
59   Bayleran JK, Yan H, Hopper CA, Simpson EM. Frequencies of cystic fibrosis mutations in the Maine population: high proportion of unknown alleles in individuals of French-Canadian ancestry. Hum. Genet. 98(2):207-9. (1996) PMID 8698344
60   Mbikay M, Tadros H, Seidah NG, Simpson EM. Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse chromosome 2. Mamm. Genome 6(11):818-9. (1995) PMID 8597642
61   Mbikay M, Seidah NG, Chrétien M, Simpson EM. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. Genomics 26(1):123-9. (1995) PMID 7782070
62   Johnson KA, Lerner CP, Di Lacio LC, Laird PW, Sharpe AH, Simpson EM. Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections. Nucleic Acids Res. 23(7):1273-5. (1995) PMID 7739908
63   Zambrowicz BP, Zimmermann JW, Harendza CJ, Simpson EM, Page DC, Brinster RL, Palmiter RD. Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis. Development 120(6):1549-59. (1994) PMID 8050362
64   Zambrowicz BP, Findley SD, Simpson EM, Page DC, Palmiter RD. Characterization of the murine Zfy1 and Zfy2 promoters. Genomics 24(2):406-8. (1994) PMID 7698773
65   Simpson EM. Book Review: Molecular Genetics of Sex Determination New England Journal of Medicine 331(13):885-886. (1994)
66   Simpson EM, Page DC. An interstitial deletion in mouse Y chromosomal DNA created a transcribed Zfy fusion gene. Genomics 11(3):601-8. (1991) PMID 1774064
67   Mardon G, Luoh SW, Simpson EM, Gill G, Brown LG, Page DC. Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers. Mol. Cell. Biol. 10(2):681-8. (1990) PMID 2105457
68   Page DC, Disteche CM, Simpson EM, de la Chapelle A, Andersson M, Alitalo T, Brown LG, Green P, Akots G. Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs. Genomics 7(1):37-46. (1990) PMID 1970799
69   Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG. The sex-determining region of the human Y chromosome encodes a finger protein. Cell 51(6):1091-104. (1987) PMID 3690661
70   Himmelfarb HJ, Simpson EM, Friesen JD. Isolation and characterization of temperature-sensitive RNA polymerase II mutants of Saccharomyces cerevisiae. Mol. Cell. Biol. 7(6):2155-64. (1987) PMID 3299061
71   Elliott EM, Henderson G, Sarangi F, Ling V. Complete sequence of three alpha-tubulin cDNAs in Chinese hamster ovary cells: each encodes a distinct alpha-tubulin isoprotein. Mol. Cell. Biol. 6(3):906-13. (1986) PMID 3773896
72   Elliott EM, Okayama H, Sarangi F, Henderson G, Ling V. Differential expression of three alpha-tubulin genes in Chinese hamster ovary cells. Mol. Cell. Biol. 5(1):236-41. (1985) PMID 3982416
73   Elliott EM, Sarangi F, Henderson G, Ling V. Cloning of 11 alpha-tubulin gene sequences from the genome of Chinese hamster ovary cells. Can. J. Biochem. Cell Biol. 63(6):511-8. (1985) PMID 2931165
74   Elliott EM, Ling V. Selection and characterization of Chinese hamster ovary cell mutants resistant to melphalan (L-phenylalanine mustard). Cancer Res. 41(2):393-400. (1981) PMID 7448783

Invited Submissions, Books, Chapters, Letters, and Editorials

1   Chapter   Schimenti J, and Simpson EM. Mammalian Genome in Encyclopedia of Molecular Biology and Molecular Medicine R.S. Meyers, ed. (New York: VCH) (1996)
2   Chapter   Schneider-Gadicke A, Beer-Romero P, Brown LG, Simpson EM, Swendeman S, Page DC. The sex-determining function of the human Y Chromosome Biotechnology and Human Genetic Predisposition to Disease, Wiley-Liss, Inc. 126:13-20. (1990)
3   Doctoral Thesis   Elliott, E.M.. The α-tubulin gene family of Chinese Hamster Ovary Cells University of Toronto (1985)
4   Masters Thesis   Elliott, E.M.. Selection and characterization of Chinese Hamster Ovary Cell mutants resistant to Melphalan. University of Toronto (1980)