Daniel Goldowitz
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Daniel Goldowitz
Senior Scientist, CMMT, CFRI, UBC
Professor, Department of Medical Genetics, UBC
Canada Research Chair Tier 1
Scientific Director, NeuroDevNet NCE
Principal Investigator
Group Goldowitz Lab
Direct line +1 (604) 875-3822
Fax +1 (604) 875-3840


Location Room 2026
Centre for Molecular Medicine and Therapeutics
950 West 28th Avenue
Vancouver, BC
V5Z 4H4 Canada
Assistant Anita Sham
Direct line +1 (604) 875-3827


University of California at Irvine, Irvine, CA PhD in Psychobiology (1978) with doctoral disssertation: "Axonal Growth in the Hippocampal Formation of the Adult Rat"
University of Cincinnati, Cincinnati, OH Short Course in Electron Microscopic Autoradiography (1984)
Jackson Laboratory, Bar Harbor, ME Short Course in Mammalian and Medical Genetics (1979, 1991)
University of California at Santa Cruz, Santa Cruz, CA, BA in Psychology (1973)
Antioch College, Yellow Springs, OH (1968-1970)
John Marshall High School, Los Angeles, CA (1968)


Please visit my lab website to learn more about my research interests and projects.


As Scientific Director of NeuroDevNet since 2009, Dr. Goldowitz interacts with 200+ brain development researchers and professionals across Canada. For a complete list of these individuals, please go to: http://www.neurodevnet.ca/about/people

Key collaborators in other projects:
Dr. Guy Mittleman from University of Memphis, USA
Dr. Kristin Hamre from University of Tennessee, USA
Dr. Harukazu Suzuki from Omics Science Center, RIKEN, Yokohama Institute, Japan


Editorial Board, J. Neurogenetics, Cerebellum, Genes, Brain and Behavior


2009 Applebaum Visiting Professor, University of Florida


Year 2015
April 20 Science on the Swan Conference, University of Western Australia Australia, invited speaker. Title: Mouse models of neuronal development.
March 9 Ben-Gurion University - Canadian Researchers Collaboration Meeting Tel Aviv, Israel, invited speaker. Title: Neurodevelopmental disorders: Genetics".
Year 2014
Nov 17 Innovating Child and Family Health Conference, hosted by CIHR Ottawa, invited speaker. Title: Improving Children's Mental Health and Neurodevelopment.
Nov 14 Seeds of Violence conference: Building a Trauma Reponsive Community. University of Florida, Gainesville, USA. Title: Latest Research on Trauma and the Brain.
Year 2013
May 3 IMFAR Educatoinal Symposia: Cerebellar Contribution to Autism Spectrum Disorders Basque Country, Spain, invited speaker. Title: Integratoin of Molecular, Anatomical and Functional Roles of the Cerebellum in Autism Spectrum Disorders.
Year 2012
May 24 INCF (international neuroinformatics coordinating facility), Vancouver, invited speaker
May 14 Research Canada, Ottawa, Ontario, NeuroDevNet presenter at booth
May 11 NeuroDevNet-sponsored CP in motion forum , Edmonton, invited speaker
April 29 Canadian Human Genetics Conference, Ontario, invited speaker
April 3 Children's Hospital of Chongqing Medical University, Chongqing, China, invited presented
March 26 NeuroDevNet's Day on the Hill event , Ottawa, meet with senators, parliamentarians and the general public to inform/answer on brain development
February 10 British Columbia Cross-ministerial meeting on Autism, Vancouver, panel member

Year 2011
November 11 Society of Neuroscience meeting, Washington DC, invited speaker
October 26 International Children's Well-Being Symposium, Mount Royal University, Calgary, invited speaker
October 22 Mukibaum International Sensory Conferences, Toronto, speaker
October 17 FANTOM5 Koyo Meeting at the Riken Institute, Yokohama, Japan, speaker
July 31 Canada-Israel Technology Innovation Meeting - Brain Research Group, Tel Aviv, Israel, Discussant
June 20 NeuroDevNet Annual Meeting, Vanocuver, organizer and speaker
March 2 1st Biennial ART - NeuroDevNet Winter Institute, Banff, Canada, organizer and presenter

Year 2010
November 11 NIH-INIA retreat, San Diego, USA, presenter
November 4 Seattle Children's Research Institute, Seattle, USA, presenter
October 20 UBC Neurology Grand Rounds , presenter
September 14 11th Annual Fetal Alcohol Canadian Experience Research Rountable, Vancouver, presenter
June 6 NeuroDevNet Annual General Meeting, Montreal, Quebec, presenter
April 23 Celebrate BC Autism, Autism Community Training, Vancouver, Keynote presenter
March 19 University of Tennessee-ORNL-KBRIN Bioinformatics Summit, Cadiz, Kentucky, USA, organizer and speaker
February 11 Duke-NUS Graduate Medical School, Singapore, speaker
January 20 University of Toronto, Ontario, invited speaker

Year 2009
October 17 Society for Neuroscience meeting, Chicago, USA, symposium organizer and speaker
October 16 Society for Research on the Cerebellum, Chicago, USA, symposium speaker
June 8 Janelia Farm, Maryland, speaker
May 27 HDF Neuroinflammation meeting, New York City, speaker
February 23 Emory University, Atlanta, speaker
January 10 INIA retreat at Memphis, USA, presenter

Year 2008
November 11 National Institute of Drug Abuse, workforce development and collaboration in addiction genetics meeting, presenter
July 11 Society for Research on the Cerebellum, Inaugrual Cerebellar Symposium, Geneva, Switzerland, Organizer
June 27 Research Society of Alcoholism , Washington, DC, speaker
May 5 IBANGS meeting, Oregon, speaker
March 12 Spring Brain Conference, California, USA, speaker
February 20 Autism Spectrum Disorder Teleconference - Canadian-American Research Consortium, speaker


Reviews and Invited Reviews

1   Review   Reynolds JN, Weinberg J, Clarren S, Beaulieu C, Rasmussen C, Kobor M, Dube MP, Goldowitz D. Fetal alcohol spectrum disorders: gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes. Semin Pediatr Neurol 18(1):49-55. (2011) PMID 21575841
2   Review   Lewis NJ, Goldowitz D. NeuroDevNet: A Canada Network of Centres of Excellence--to realize a vision by effective operations and collaborative mechanisms. Semin Pediatr Neurol 18(1):5-9. (2011) PMID 21575834
3   Review   Goldowitz D, McArthur D. The NeuroDevNet vision. Semin Pediatr Neurol 18(1):2-4. (2011) PMID 21575833
4   Review   Shevell M, Goldowitz D. Inter-disciplinary research in the pediatric neurosciences: the NeuroDevNet model. Introduction. Semin Pediatr Neurol 18(1):1. (2011) PMID 21575832

Journal Articles

1   de Leeuw CN, Dyka FM, Boye SL, Laprise S, Zhou M, Chou AY, Borretta L, McInerny SC, Banks KG, Portales-Casamar E, Swanson MI, D'Souza CA, Boye SE, Jones SJ, Holt RA, Goldowitz D, Hauswirth WW, Wasserman WW, Simpson EM. Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors. Mol Ther Methods Clin Dev 1:5. (2014) PMID 24761428
2   . A promoter-level mammalian expression atlas. Nature 507(7493):462-70. (2014) PMID 24670764
3   Yoo JY, Mak GK, Goldowitz D. The effect of hemorrhage on the development of the postnatal mouse cerebellum. Exp. Neurol. 252:85-94. (2014) PMID 24252180
4   Schmouth JF, Castellarin M, Laprise S, Banks KG, Bonaguro RJ, McInerny SC, Borretta L, Amirabbasi M, Korecki AJ, Portales-Casamar E, Wilson G, Dreolini L, Jones SJ, Wasserman WW, Goldowitz D, Holt RA, Simpson EM. Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice. BMC Biol. 11:106. (2013) PMID 24124870
5   Goldowitz D. Excessive activation of tissue plasminogen activator makes a mouse nervous. Proc. Natl. Acad. Sci. U.S.A. 110(27):10882-3. (2013) PMID 23792578
6   Dickson PE, Corkill B, McKimm E, Miller MM, Calton MA, Goldowitz D, Blaha CD, Mittleman G. Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome. Behav. Brain Res. 252:126-35. (2013) PMID 23747611
7   Rogers TD, McKimm E, Dickson PE, Goldowitz D, Blaha CD, Mittleman G. Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research. Front Syst Neurosci 7:15. (2013) PMID 23717269
8   Rogers TD, Dickson PE, McKimm E, Heck DH, Goldowitz D, Blaha CD, Mittleman G. Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder. Cerebellum 12(4):547-56. (2013) PMID 23436049
9   Yoo JY, Larouche M, Goldowitz D. The Expression of HDAC1 and HDAC2 During Cerebellar Cortical Development. Cerebellum 12(4):534-46. (2013) PMID 23436026
10   Poon A, Goldowitz D. Effects of age and strain on cell proliferation in the mouse rostral migratory stream. Neurobiol. Aging (2013) PMID 23369547
11   Qiao S, Kim SH, Heck D, Goldowitz D, Ledoux MS, Homayouni R. Dab2IP GTPase Activating Protein Regulates Dendrite Development and Synapse Number in Cerebellum. PLoS ONE 8(1):e53635. (2013) PMID 23326475
12   Dubose CS, Chesler EJ, Goldowitz D, Hamre KM. Use of the Expanded Panel of BXD Mice Narrow QTL Regions in Ethanol-Induced Locomotor Activation and Motor Incoordination. Alcohol. Clin. Exp. Res. 37(1):170-83. (2013) PMID 23289978
13   Liu L, Hamre KM, Goldowitz D. Kainic acid-induced neuronal degeneration in hippocampal pyramidal neurons is driven by both intrinsic and extrinsic factors: analysis of FVB/N↔C57BL/6 chimeras. J. Neurosci. 32(35):12093-101. (2012) PMID 22933793
14   Ha TJ, Swanson DJ, Kirova R, Yeung J, Choi K, Tong Y, Chesler EJ, Goldowitz D. Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum. Eur. J. Neurosci. 36(7):2888-98. (2012) PMID 22817342
15   Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ, Chauhan A, Chauhan V, Dager SR, Dickson PE, Estes AM, Goldowitz D, Heck DH, Kemper TL, King BH, Martin LA, Millen KJ, Mittleman G, Mosconi MW, Persico AM, Sweeney JA, Webb SJ, Welsh JP. Consensus Paper: Pathological Role of the Cerebellum in Autism. (2012) PMID 22370873
16   Goldowitz D. Linking early brain and biological development to psychiatry. J Can Acad Child Adolesc Psychiatry 20(4):252. (2011) PMID 22114606
17   Tong Y, Ha TJ, Liu L, Nishimoto A, Reiner A, Goldowitz D. Spatial and Temporal Requirements for huntingtin (Htt) in Neuronal Migration and Survival during Brain Development. J. Neurosci. 31(41):14794-9. (2011) PMID 21994396
18   Ouyang Z, Song M, Güth R, Ha TJ, Larouche M, Goldowitz D. Conserved and differential gene interactions in dynamical biological systems. Bioinformatics 27(20):2851-8. (2011) PMID 21840874
19   Rogers TD, Dickson PE, Heck DH, Goldowitz D, Mittleman G, Blaha CD. Connecting the dots of the cerebro-cerebellar role in cognitive function: Neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex. Synapse 65(11):1204-12. (2011) PMID 21638338
20   Mittleman G, Call SB, Cockroft JL, Goldowitz D, Matthews DB, Blaha CD. Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice. Alcohol 45(4):325-39. (2011) PMID 21354763
21   Di Curzio DL, Goldowitz D. The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice. Mamm. Genome 22(3-4):209-34. (2011) PMID 21347846
22   Dickson PE, Rogers TD, Lester DB, Miller MM, Matta SG, Chesler EJ, Goldowitz D, Blaha CD, Mittleman G. Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine. Psychopharmacology (Berl.) 215(4):631-42. (2011) PMID 21212937
23   Swanson DJ, Goldowitz D. Experimental Sey mouse chimeras reveal the developmental deficiencies of Pax6-null granule cells in the postnatal cerebellum. Dev. Biol. 351(1):1-12. (2011) PMID 21126516
24   Lehman A, du Souich C, Chai D, Eydoux P, Huang J, Fok A, Avila L, Swingland J, Delaney A, McGillivray B, Goldowitz D, Argiropoulos B, Kobor M, Boerkoel C. 19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression. (2010) PMID 21204797
25   Swanson DJ, Steshina EY, Wakenight P, Aldinger KA, Goldowitz D, Millen KJ, Chizhikov VV. Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele. Eur. J. Neurosci. 32(5):707-16. (2010) PMID 20722722
26   Poon A, Li Z, Wolfe GW, Lu L, Williams RW, Hayes NL, Nowakowski RS, Goldowitz D. Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur. J. Neurosci. 32(4):523-37. (2010) PMID 20718853
27   Samaan G, Yugo D, Rajagopalan S, Wall J, Donnell R, Goldowitz D, Gopalakrishnan R, Venkatachalam S. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Biochem. Biophys. Res. Commun. 400(1):60-5. (2010) PMID 20691664
28   Fyfe JC, Al-Tamimi RA, Castellani RJ, Rosenstein D, Goldowitz D, Henthorn PS. Inherited neuroaxonal dystrophy in dogs causing lethal, fetal-onset motor system dysfunction and cerebellar hypoplasia. J. Comp. Neurol. 518(18):3771-84. (2010) PMID 20653033
29   Dickson PE, Rogers TD, Del Mar N, Martin LA, Heck D, Blaha CD, Goldowitz D, Mittleman G. Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss. Neurobiol Learn Mem 94(2):220-8. (2010) PMID 20566377
30   Martin LA, Goldowitz D, Mittleman G. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur. J. Neurosci. 31(3):544-55. (2010) PMID 20105240
31   Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav. 9(2):129-59. (2010) PMID 19958391
32   Freedman R, Goldowitz D. Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Prog. Neurobiol. 90(2):263-75. (2010) PMID 19853005
33   Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci 3:55. (2009) PMID 20582282
34   Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol 43(6):421-31. (2009) PMID 19801272
35   Jiao Y, Cai C, Kermany MH, Yan J, Cai Q, Miller D, Goldowitz D, Li X, Yoo TJ, Gu W. ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice. Genes Genet. Syst. 84(3):219-24. (2009) PMID 19745570
36   Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A. CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse. Neurobiol. Dis. 33(3):315-30. (2009) PMID 19027857
37   Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics 93(3):196-204. (2009) PMID 18950699
38   Crusio WE, Goldowitz D, Holmes A, Wolfer D. Standards for the publication of mouse mutant studies. Genes Brain Behav. 8(1):1-4. (2009) PMID 18778401
39   Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 27(24):3221-34. (2008) PMID 19037259
40   Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A. CAG repeat lengths >/=335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse. Neurobiol. Dis. (2008) PMID 19027857
41   Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics (2008) PMID 18950699
42   Crusio WE, Goldowitz D, Holmes A, Wolfer D. Standards for the publication of mouse mutant studies. Genes Brain Behav. (2008) PMID 18778401
43   D'Souza CA, Chopra V, Varhol R, Xie YY, Bohacec S, Zhao Y, Lee LL, Bilenky M, Portales-Casamar E, He A, Wasserman WW, Goldowitz D, Marra MA, Holt RA, Simpson EM, Jones SJ. Identification of a set of genes showing regionally enriched expression in the mouse brain. BMC Neurosci 9:66. (2008) PMID 18625066
44   Matthews DB, Morrow AL, O'Buckley T, Flanigan TJ, Berry RB, Cook MN, Mittleman G, Goldowitz D, Tokunaga S, Silvers JM. Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice. Alcohol 42(6):469-76. (2008) PMID 18599253
45   Matthews DB, Chesler EJ, Cook MN, Cockroft J, Philip VM, Goldowitz D. Genetic mapping of vocalization to a series of increasing acute footshocks using B6.A consomic and B6.D2 congenic mouse strains. Behav. Genet. 38(4):417-23. (2008) PMID 18535899
46   Mittleman G, Goldowitz D, Heck DH, Blaha CD. Cerebellar modulation of frontal cortex dopamine efflux in mice: relevance to autism and schizophrenia. Synapse 62(7):544-50. (2008) PMID 18435424
47   Reiner A, Del Mar N, Deng YP, Meade CA, Sun Z, Goldowitz D. R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice. J. Comp. Neurol. 505(6):603-29. (2007) PMID 17948889
48   Liu L, Geisert EE, Frankfurter A, Spano AJ, Jiang CX, Yue J, Dragatsis I, Goldowitz D. A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein. Genesis 45(9):560-9. (2007) PMID 17868115
49   Hamre KM, Goldowitz D, Wilkinson S, Matthews DB. Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. Behav. Neurosci. 121(4):665-78. (2007) PMID 17663592
50   Cook MN, Dunning JP, Wiley RG, Chesler EJ, Johnson DK, Miller DR, Goldowitz D. Neurobehavioral mutants identified in an ENU-mutagenesis project. Mamm. Genome 18(8):559-72. (2007) PMID 17629744
51   Li S, Goldowitz D, Swanson DJ. The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras. Invest. Ophthalmol. Vis. Sci. 48(7):3292-300. (2007) PMID 17591901
52   Matera I, Cockroft JL, Moran JL, Beier DR, Goldowitz D, Pavan WJ. A mouse model of Waardenburg syndrome type IV resulting from an ENU-induced mutation in endothelin 3. Pigment Cell Res. 20(3):210-5. (2007) PMID 17516928
53   Bao L, Peirce JL, Zhou M, Li H, Goldowitz D, Williams RW, Lu L, Cui Y. An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Hum. Mol. Genet. 16(11):1381-90. (2007) PMID 17428815
54   Du X, Jensen P, Goldowitz D, Hamre KM. Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice. Dev. Biol. 305(2):430-8. (2007) PMID 17397818
55   Thornton JD, Swanson DJ, Mary MN, Pei D, Martin AC, Pounds S, Goldowitz D, Skapek SX. Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor. Invest. Ophthalmol. Vis. Sci. 48(2):491-9. (2007) PMID 17251441
56   Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y. PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res. 35(Database issue):D51-4. (2007) PMID 17099235
57   Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Huntingtin inhibits caspase-3 activation. EMBO J. 25(24):5896-906. (2006) PMID 17124493
58   Kermany MH, Parker LL, Guo YK, Miller D, Swanson DJ, Yoo TJ, Goldowitz D, Zuo J. Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. Hear. Res. 220(1-2):76-86. (2006) PMID 16949226
59   Bao L, Wei L, Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y. Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships. Mamm. Genome 17(6):575-83. (2006) PMID 16783639
60   Goldowitz D, Matthews DB, Hamre KM, Mittleman G, Chesler EJ, Becker HC, Lopez MF, Jones SR, Mathews TA, Miles MF, Kerns R, Grant KA. Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. Alcohol. Clin. Exp. Res. 30(6):1066-78. (2006) PMID 16737467
61   Martin LA, Goldowitz D, Mittleman G. Sustained attention in the mouse: a study of the relationship with the cerebellum. Behav. Neurosci. 120(2):477-81. (2006) PMID 16719710
62   Jablonski MM, Wang X, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz D. The Tennessee Mouse Genome Consortium: identification of ocular mutants. Vis. Neurosci. 22(5):595-604. (2005) PMID 16332270
63   Swanson DJ, Tong Y, Goldowitz D. Disruption of cerebellar granule cell development in the Pax6 mutant, Sey mouse. Brain Res. Dev. Brain Res. 160(2):176-93. (2005) PMID 16289327
64   Valentine WM, Hill KE, Austin LM, Valentine HL, Goldowitz D, Burk RF. Brainstem axonal degeneration in mice with deletion of selenoprotein p. 33(5):570-6. (2005) PMID 16105800
65   Jablonski MM, Dalke C, Wang X, Lu L, Manly KF, Pretsch W, Favor J, Pardue MT, Rinchik EM, Williams RW, Goldowitz D, Graw J. An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Mol. Vis. 11:569-81. (2005) PMID 16088326
66   Sun Z, Wang HB, Deng YP, Lei WL, Xie JP, Meade CA, Del Mar N, Goldowitz D, Reiner A. Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice. Neurobiol. Dis. 20(3):907-17. (2005) PMID 15990326
67   Goswami J, Martin LA, Goldowitz D, Beitz AJ, Feddersen RM. Enhanced Purkinje cell survival but compromised cerebellar function in targeted anti-apoptotic protein transgenic mice. Mol. Cell. Neurosci. 29(2):202-21. (2005) PMID 15911345
68   Jiao Y, Li X, Beamer WG, Yan J, Tong Y, Goldowitz D, Roe B, Gu W. A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14. Mamm. Genome 16(1):20-31. (2005) PMID 15674730
69   Vig J, Goldowitz D, Steindler DA, Eisenman LM. Compartmentation of the reeler cerebellum: segregation and overlap of spinocerebellar and secondary vestibulocerebellar fibers and their target cells. Neuroscience 130(3):735-44. (2005) PMID 15590156
70   Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ. Implementing large-scale ENU mutagenesis screens in North America. Genetica 122(1):51-64. (2004) PMID 15619961
71   Goldowitz D, Frankel WN, Takahashi JS, Holtz-Vitaterna M, Bult C, Kibbe WA, Snoddy J, Li Y, Pretel S, Yates J, Swanson DJ. Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. Brain Res. Mol. Brain Res. 132(2):105-15. (2004) PMID 15582151
72   Martin LA, Escher T, Goldowitz D, Mittleman G. A relationship between cerebellar Purkinje cells and spatial working memory demonstrated in a lurcher/chimera mouse model system. Genes Brain Behav. 3(3):158-66. (2004) PMID 15140011
73   Bult C, Kibbe WA, Snoddy J, Vitaterna M, Swanson D, Pretel S, Li Y, Hohman MM, Rinchik E, Takahashi JS, Frankel WN, Goldowitz D. A genome end-game: understanding gene function in the nervous system. Nat. Neurosci. 7(5):484-5. (2004) PMID 15114363
74   Jensen P, Smeyne R, Goldowitz D. Analysis of cerebellar development in math1 null embryos and chimeras. J. Neurosci. 24(9):2202-11. (2004) PMID 14999071
75   Reiner A, Dragatsis I, Zeitlin S, Goldowitz D. Wild-type huntingtin plays a role in brain development and neuronal survival. Mol. Neurobiol. 28(3):259-76. (2003) PMID 14709789
76   Martin LA, Goldowitz D, Mittleman G. The cerebellum and spatial ability: dissection of motor and cognitive components with a mouse model system. Eur. J. Neurosci. 18(7):2002-10. (2003) PMID 14622233
77   Sun Z, Del Mar N, Meade C, Goldowitz D, Reiner A. Differential changes in striatal projection neurons in R6/2 transgenic mice for Huntington's disease. Neurobiol. Dis. 11(3):369-85. (2002) PMID 12586547
78   Jensen P, Zoghbi HY, Goldowitz D. Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J. Neurosci. 22(18):8110-6. (2002) PMID 12223565
79   Meade CA, Deng YP, Fusco FR, Del Mar N, Hersch S, Goldowitz D, Reiner A. Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice. J. Comp. Neurol. 449(3):241-69. (2002) PMID 12115678
80   Yang H, Scholich K, Poser S, Storm DR, Patel TB, Goldowitz D. Developmental expression of PAM (protein associated with MYC) in the rodent brain. Brain Res. Dev. Brain Res. 136(1):35-42. (2002) PMID 12036515
81   Martin LA, Tan SS, Goldowitz D. Clonal architecture of the mouse hippocampus. J. Neurosci. 22(9):3520-30. (2002) PMID 11978829
82   Gattone VH, Goldowitz D. The renal glomerulus and vasculature in 'aggregation' chimeric mice. Nephron 90(3):267-72. (2002) PMID 11867947
83   Beranova-Giorgianni S, Pabst MJ, Russell TM, Giorgianni F, Goldowitz D, Desiderio DM. Preliminary analysis of the mouse cerebellum proteome. Brain Res. Mol. Brain Res. 98(1-2):135-40. (2002) PMID 11834305
84   Yang H, Jensen P, Goldowitz D. The community effect and Purkinje cell migration in the cerebellar cortex: analysis of scrambler chimeric mice. J. Neurosci. 22(2):464-70. (2002) PMID 11784791
85   Reiner A, Del Mar N, Meade CA, Yang H, Dragatsis I, Zeitlin S, Goldowitz D. Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice. J. Neurosci. 21(19):7608-19. (2001) PMID 11567051
86   Beierbach E, Park C, Ackerman SL, Goldowitz D, Hawkes R. Abnormal dispersion of a purkinje cell subset in the mouse mutant cerebellar deficient folia (cdf). J. Comp. Neurol. 436(1):42-51. (2001) PMID 11413545
87   Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A, . Sequence interpretation. Functional annotation of mouse genome sequences. Science 291(5507):1251-5. (2001) PMID 11233449
88   Fain JN, Del Mar NA, Meade CA, Reiner A, Goldowitz D. Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation. Hum. Mol. Genet. 10(2):145-52. (2001) PMID 11152662
89   Goldowitz D, Hamre KM, Przyborski SA, Ackerman SL. Granule cells and cerebellar boundaries: analysis of Unc5h3 mutant chimeras. J. Neurosci. 20(11):4129-37. (2000) PMID 10818148
90   Rice DS, Goldowitz D, Williams RW, Hamre K, Johnson PT, Tan SS, Reese BE. Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice. Dev. Biol. 216(1):41-56. (1999) PMID 10588862
91   Jensen P, Surmeier DJ, Goldowitz D. Rescue of cerebellar granule cells from death in weaver NR1 double mutants. J. Neurosci. 19(18):7991-8. (1999) PMID 10479699
92   Tang Q, Rice DS, Goldowitz D. Disrupted retinal development in the embryonic belly spot and tail mutant mouse. Dev. Biol. 207(1):239-55. (1999) PMID 10049578
93   Lombroso PJ, Goldowitz D. Drain development, VIII: the reeler mouse. 155(12):1660. (1998) PMID 9842772
94   Goldowitz D, Hamre K. The cells and molecules that make a cerebellum. Trends Neurosci. 21(9):375-82. (1998) PMID 9735945
95   Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development 125(18):3719-29. (1998) PMID 9716537
96   McAndrew PE, Frostholm A, Evans JE, Zdilar D, Goldowitz D, Chiu IM, Burghes AH, Rotter A. Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex. J. Comp. Neurol. 391(4):444-55. (1998) PMID 9486824
97   Williams RW, Strom RC, Goldowitz D. Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. J. Neurosci. 18(1):138-46. (1998) PMID 9412494
98   Mullen RJ, Hamre KM, Goldowitz D. Cerebellar mutant mice and chimeras revisited. 5(1):43-55. (1997) PMID 9509517
99   Chen SC, Ehrhard P, Goldowitz D, Smeyne RJ. Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse. Brain Res. 778(2):251-64. (1997) PMID 9459542
100   González JL, Russo CJ, Goldowitz D, Sweet HO, Davisson MT, Walsh CA. Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype. J. Neurosci. 17(23):9204-11. (1997) PMID 9364067
101   Goldowitz D, Cushing RC, Laywell E, D'Arcangelo G, Sheldon M, Sweet HO, Davisson M, Steindler D, Curran T. Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin. J. Neurosci. 17(22):8767-77. (1997) PMID 9348346
102   Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell BW, Cooper JA, Goldowitz D, Curran T. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature 389(6652):730-3. (1997) PMID 9338784
103   Hamre KM, Goldowitz D. meander tail acts intrinsic to granule cell precursors to disrupt cerebellar development: analysis of meander tail chimeric mice. Development 124(21):4201-12. (1997) PMID 9334269
104   Rice DS, Tang Q, Williams RW, Harris BS, Davisson MT, Goldowitz D. Decreased retinal ganglion cell number and misdirected axon growth associated with fissure defects in Bst/+ mutant mice. Invest. Ophthalmol. Vis. Sci. 38(10):2112-24. (1997) PMID 9331275
105   Ezer AD, Williams RW, Goldowitz D. Arbitrary primer PCR of dog DNA with estimates of average heterozygosity. J. Hered. 87(6):450-5. (1997) PMID 8981763
106   Goldowitz D, Rice DS, Williams RW. Clonal architecture of the mouse retina. Prog. Brain Res. 108:3-15. (1996) PMID 8979790
107   Williams RW, Strom RC, Rice DS, Goldowitz D. Genetic and environmental control of variation in retinal ganglion cell number in mice. J. Neurosci. 16(22):7193-205. (1996) PMID 8929428
108   Surmeier DJ, Mermelstein PG, Goldowitz D. The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells. Proc. Natl. Acad. Sci. U.S.A. 93(20):11191-5. (1996) PMID 8855331
109   Hemre KM, Keller-Peck CR, Campbell RM, Peterson AC, Mullen RJ, Goldowitz D. Annexin IV is a marker of roof and floor plate development in the murine CNS. J. Comp. Neurol. 368(4):527-37. (1996) PMID 8744441
110   Hamre KM, Goldowitz D. Analysis of gene action in the meander tail mutant mouse: examination of cerebellar phenotype and mitotic activity of granule cell neuroblasts. J. Comp. Neurol. 368(2):304-15. (1996) PMID 8725309
111   Chepenik KP, Shipman-Appasamy P, Ahn N, Goldowitz D. Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J. Craniofac. Genet. Dev. Biol. 15(4):171-81. (1996) PMID 8719346
112   Rice DS, Williams RW, Ward-Bailey P, Johnson KR, Harris BS, Davisson MT, Goldowitz D. Mapping the Bst mutation on mouse chromosome 16: a model for human optic atrophy. Mamm. Genome 6(8):546-8. (1995) PMID 8589526
113   Hamre KM, Chepenik KP, Goldowitz D. The annexins: specific markers of midline structures and sensory neurons in the developing murine central nervous system. J. Comp. Neurol. 352(3):421-35. (1995) PMID 7706559
114   Rice DS, Williams RW, Goldowitz D. Genetic control of retinal projections in inbred strains of albino mice. J. Comp. Neurol. 354(3):459-69. (1995) PMID 7608332
115   Goldowitz D, Smeyne RJ. Tune into the weaver channel. Nat. Genet. 11(2):107-9. (1995) PMID 7550328
116   Rothman TP, Goldowitz D, Gershon MD. Inhibition of migration of neural crest-derived cells by the abnormal mesenchyme of the presumptive aganglionic bowel of ls/ls mice: analysis with aggregation and interspecies chimeras. Dev. Biol. 159(2):559-73. (1993) PMID 8405679
117   Williams RW, Goldowitz D. Structure of clonal and polyclonal cell arrays in chimeric mouse retina. Proc. Natl. Acad. Sci. U.S.A. 89(4):1184-8. (1992) PMID 1741373
118   Knobler RL, Marini JC, Goldowitz D, Lublin FD. Distribution of the blood-brain barrier in heterotopic brain transplants and its relationship to the lesions of EAE. J. Neuropathol. Exp. Neurol. 51(1):36-9. (1992) PMID 1371310
119   Williams RW, Goldowitz D. Lineage versus environment in embryonic retina: a revisionist perspective. Trends Neurosci. 15(10):368-73. (1992) PMID 1279856
120   Smeyne RJ, Pickford LB, Rouse RV, Napieralski J, Goldowitz D. Abnormalities in premigratory granule cells in the weaver cerebellum defined by monoclonal antibody OZ42. Anat. Embryol. 183(3):213-9. (1991) PMID 2042747
121   Appasamy PM, Pendino K, Schmidt RR, Chepenik KP, Prystowsky MB, Goldowitz D. Expression of prostaglandin G/H synthase (cyclooxygenase) during murine fetal thymic development. Cell. Immunol. 137(2):341-57. (1991) PMID 1716517
122   Smeyne RJ, Goldowitz D. Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). Brain Res. Dev. Brain Res. 54(2):282-6. (1990) PMID 2397591
123   Smeyne RJ, Goldowitz D. Purkinje cell loss is due to a direct action of the weaver gene in Purkinje cells: evidence from chimeric mice. Brain Res. Dev. Brain Res. 52(1-2):211-8. (1990) PMID 2331788
124   Goldowitz D, Barthels D, Lorenzon N, Jungblut A, Wille W. NCAM gene expression during the development of cerebellum and dentate gyrus in the mouse. Brain Res. Dev. Brain Res. 52(1-2):151-60. (1990) PMID 2331783
125   Heckroth JA, Goldowitz D, Eisenman LM. Olivocerebellar fiber maturation in normal and lurcher mutant mice: defective development in lurcher. J. Comp. Neurol. 291(3):415-30. (1990) PMID 2298941
126   Heckroth JA, Goldowitz D, Eisenman LM. Purkinje cell reduction in the reeler mutant mouse: a quantitative immunohistochemical study. J. Comp. Neurol. 279(4):546-55. (1989) PMID 2918086
127   Smeyne RJ, Goldowitz D. Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study. J. Neurosci. 9(5):1608-20. (1989) PMID 2723742
128   Goldowitz D. Cell allocation in mammalian CNS formation: evidence from murine interspecies aggregation chimeras. Neuron 3(6):705-13. (1989) PMID 2642015
129   Goldowitz D. The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: evidence from homozygous weaver chimeras. Neuron 2(6):1565-75. (1989) PMID 2627379
130   Reeves RH, Crowley MR, Lorenzon N, Pavan WJ, Smeyne RJ, Goldowitz D. The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Genomics 5(3):522-6. (1989) PMID 2575584
131   Lublin FD, Knobler RL, Marini J, Goldowitz D. Brain transplantation in genetic analysis of experimental allergic encephalomyelitis. Ann. N. Y. Acad. Sci. 540:252-4. (1988) PMID 3207253
132   Slemmon JR, Goldowitz D, Blacher R, Morgan JI. Evidence for the transneuronal regulation of cerebellin biosynthesis in developing Purkinje cells. J. Neurosci. 8(12):4603-11. (1988) PMID 3199194
133   Herget T, Goldowitz D, Oelemann W, Starzinski-Powitz A. Description of putative ribosomal RNAs with low abundance, developmental regulation, and the identifier sequence. Exp. Cell Res. 176(1):141-54. (1988) PMID 2453368
134   Goldowitz D. Cell partitioning and mixing in the formation of the CNS: analysis of the cortical somatosensory barrels in chimeric mice. Brain Res. 432(1):1-9. (1987) PMID 3651825
135   Goldowitz D, Knobler RL, Lublin FD. Heterotopic brain transplants in the study of experimental allergic encephalomyelitis. Exp. Neurol. 97(3):653-61. (1987) PMID 3622716
136   Schaal H, Goldowitz D, Heinlein UA, Unterbeck A, Ruppert C, Papenbrock T, Müller-Hill B, Vielmetter W, Wille W. A highly abundant transcript in adult murine cerebellar granule cells contains repetitive sequences homologous to L1. J. Neurosci. 7(7):2041-8. (1987) PMID 2441004
137   Goldowitz D, Koch J. Performance of normal and neurological mutant mice on radial arm maze and active avoidance tasks. Behav. Neural Biol. 46(2):216-26. (1986) PMID 3767833
138   Ruppert C, Goldowitz D, Wille W. Proto-oncogene c-myc is expressed in cerebellar neurons at different developmental stages. EMBO J. 5(8):1897-901. (1986) PMID 2428614
139   Goldowitz D, Shipman PM, Porter JF, Schmidt RR. Longitudinal assessment of immunologic abnormalities of mice with the autosomal recessive mutation, "wasted". J. Immunol. 135(3):1806-12. (1985) PMID 4020135
140   Goldowitz D, Seiger A, Olson L. Degree of hyperinnervation of area dentata by locus coeruleus in the presence of septum or entorhinal cortex as studied by sequential intraocular triple transplantation. 56(2):351-60. (1984) PMID 6479268
141   Goldowitz D, Seiger A, Olson L. Regulation of axonal ingrowth into area dentata as studied by sequential, double intraocular brain tissue transplantation. J. Comp. Neurol. 227(1):50-62. (1984) PMID 6470210
142   Wille W, Goldowitz D, Seiger A, Olson L. The neurological mutation staggerer is expressed in embryonic cerebellar transplants matured in the anterior eye chamber of normal mice. Neurosci. Lett. 42(1):1-6. (1983) PMID 6657141
143   Goldowitz D, Mullen RJ. Granule cell as a site of gene action in the weaver mouse cerebellum: evidence from heterozygous mutant chimeras. J. Neurosci. 2(10):1474-85. (1982) PMID 7119868
144   Goldowitz D, Seiger A, Olson L. Anatomy of the isolated area dentata grown in the rat anterior eye chamber. J. Comp. Neurol. 208(4):382-400. (1982) PMID 7119167
145   Goldowitz D, Mullen RJ. Nuclear morphology of ichthyosis mutant mice as a cell marker in chimeric brain. Dev. Biol. 89(1):261-7. (1982) PMID 7054010
146   Goldowitz D, Vincent SR, Wu JY, Hökfelt T. Immunohistochemical demonstration of plasticity in GABA neurons of the adult rat dentate gyrus. Brain Res. 238(2):413-20. (1982) PMID 7046874
147   Goldowitz D, Cotman CW. Axonal transport and axon sprouting in the adult rat dentate gyrus: an autoradiographic study. Neuroscience 5(12):2163-74. (1980) PMID 6162129
148   Goldowitz D, Cotman CW. Do neurotrophic interactions control synapse formation in the adult rat brain? Brain Res. 181(2):325-44. (1980) PMID 6153147
149   Goldowitz D, Scheff SW, Cotman CW. The specificity of reactive synaptogenesis: a comparative study in the adult rat hippocampal formation. Brain Res. 170(3):427-41. (1979) PMID 466422
150   Goldwitz D, Cotman CW. Induction of extensive fimbrial branching in the adult rat brain. Nature 275(5675):64-7. (1978) PMID 683343
151   White WF, Goldowitz D, Lynch G, Cotman CW. Electrophysiological analysis of the projection from the contralateral entorhinal cortex to the dentate gyrus in normal rats. Brain Res. 114(2):201-9. (1976) PMID 963548
152   Goldowitz D, White WF, Steward O, Lynch G, Cotman C. Anatomical evidence for a projection from the entorhinal cortex to the contralateral dentate gyrus of the rat. Exp. Neurol. 47(3):433-41. (1975) PMID 1132457
153   Halfon N, Goldowitz D, Glotzbach S, Berger R. Decreased temporal variability in hippocampal theta rhythms of cats administered methylphenidate. 13(4):497-503. (1975) PMID 1120056
154   Goldowitz D, Buresová O, Bures J. Forgetting of lateralized engrams studied by interhemispheric conflict in rats. 8(2):183-92. (1973) PMID 4735873
155   Goldowitz D, Buresová O, Bureś J. Time labelling of independently acquired lateralized engrams in rats. Physiol. Behav. 9(5):699-704. (1973) PMID 4655162
156   . (0) PMID 24307139

Invited Submissions, Books, Chapters, Letters, and Editorials

1   Chapter   Gu W & Goldowitz D. Gene Discovery: From Positional Cloning to Genomic Cloning John Wiley & Sons, Inc N/A(Gene Discovery for Disease Models (W. Gu and Y Wang, eds)):1-10. (2011)